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Literature summary for 1.14.14.25 extracted from

  • Martin, M.G.; Perga, S.; Trovo, L.; Rasola, A.; Holm, P.; Rantamaeki, T.; Harkany, T.; Castren, E.; Chiara, F.; Dotti, C.G.
    Cholesterol loss enhances TrkB signaling in hippocampal neurons aging in vitro (2008), Mol. Biol. Cell, 19, 2101-2112.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.14.25

Cloned(Commentary)

Cloned (Comment) Organism
full ORF expression clone p46+ including the full cyp46A1 mouse open reading frame. Cyp46A1 overexpressed in 10 days in vitro hippocampal neurons Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
shRNA knockdown Mus musculus
siRNA reduction of the cholesterol 24-hydroxylase, which results in lower levels of Trk phosphorylation Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Mus musculus
-
embryo
-
 Rattus norvegicus
-
hippocampus
-
 Mus musculus
-
hippocampus
-
 Rattus norvegicus
-
neuron
-
 Mus musculus
-
neuron
-
 Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
CYP46A1
-
 Mus musculus
CYP46A1
-
 Rattus norvegicus

Expression

Organism Comment Expression
Mus musculus age-associated increase in TrkB activity correlates with a mild yet progressive loss of cholesterol, which, in turn, correlates with increased expression of the cholesterol catabolic enzyme cholesterol 24-hydroxylase. Increased expression of cholesterol-24-hydroxylase in the hippocampus of aged mice up

General Information

General Information Comment Organism
physiological function cholesterol 24-hydroxylase regulates TrkB activity in mature hippocampal neurons Mus musculus
physiological function cholesterol 24-hydroxylase regulates TrkB activity in mature hippocampal neurons Rattus norvegicus