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Literature summary for 1.14.14.25 extracted from

  • Shafaati, M.; O'Driscoll, R.; Bjoerkhem, I.; Meaney, S.
    Transcriptional regulation of cholesterol 24-hydroxylase by histone deacetylase inhibitors (2009), Biochem. Biophys. Res. Commun., 378, 689-694.
    View publication on PubMed
Search for more literature for 1.14.14.25

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Mus musculus
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 C57/B6-J mice
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Mus musculus C57B6-J
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 C57/B6-J mice
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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 Mus musculus
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brain greater CYP46A1 levels in the brain than in the liver Homo sapiens
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liver
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 Mus musculus
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liver greater CYP46A1 levels in the brain than in the liver Homo sapiens
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SH-SY5Y cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
CYP46A1
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 Mus musculus
CYP46A1
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 Homo sapiens
cytochrome P450 cholesterol 24-hydroxylase
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 Mus musculus
cytochrome P450 cholesterol 24-hydroxylase
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 Homo sapiens

Expression

Organism Comment Expression
Mus musculus intraperitoneal injection of a high dose of valproate (700 mg/kg) results in a modest induction of the mRNA expression of CYP46A1 in the liver, and CYP46A1 in the brain. Intraperitoneal injection of trichostatin A to male mice results in dose dependent increases in the expression of brain and liver CYP46A1 up
Homo sapiens marked time-dependent derepression of the expression of CYP46A1, in response to treatment with the potent histone deacetylase inhibitor trichostatin A. Treatment with 0.0005 mM trichostatin A for 48 h shows highly significant 150fold increase in CYP46A1 expression up