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Literature summary for 1.14.14.25 extracted from

  • Famer, D.; Meaney, S.; Mousavi, M.; Nordberg, A.; Bjoerkhem, I.; Crisby, M.
    Regulation of alpha- and beta-secretase activity by oxysterols: cerebrosterol stimulates processing of APP via the alpha-secretase pathway (2007), Biochem. Biophys. Res. Commun., 359, 46-50.
    View publication on PubMed
Search for more literature for 1.14.14.25

Protein Variants

Protein Variants Comment Organism
additional information polymorphisms within the CYP46A1 gene are associated with Alzheimer’s disease incidence Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 Homo sapiens a major pathway for excretion of excess cholesterol from the brain, polymorphisms within the CYP46A1 gene are associated with Alzheimer’s disease incidence. The ratio between 24S-OHC and 27-OHC is of importance for the generation of amyloid in the brain, overview (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 gene CYP46A1
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Source Tissue

Source Tissue Comment Organism Textmining
central nervous system almost exclusive expression of gene CYP46A1 Homo sapiens
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neuroblastoma cell
-
 Homo sapiens
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SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
 Homo sapiens (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 a major pathway for excretion of excess cholesterol from the brain, polymorphisms within the CYP46A1 gene are associated with Alzheimer’s disease incidence. The ratio between 24S-OHC and 27-OHC is of importance for the generation of amyloid in the brain, overview Homo sapiens (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
additional information (24S)-24-hydroxycholesterol activates alpha- and beta-secretases, while (27S)-27-hydroxycholesterol inhibits them, overview Homo sapiens ?
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 ?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens