Protein Variants | Comment | Organism |
---|---|---|
additional information | brains from mice lacking 24-hydroxylase excrete cholesterol more slowly, and the tissue compensates by suppressing the mevalonate pathway, this suppression causes a defect in learning, 24-hydroxylase knockout mice exhibit severe deficiencies in spatial, associative, and motor learning, and in hippocampal long-term potentiation, the effects of genetic elimination of 24-hydroxylase on long-term potentiation are reversed by a 20-min treatment with geranylgeraniol but not by cholesterol, phenotype, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + reduced adrenodoxin + O2 | Mus musculus | enzyme deficiency leads to a suppression of the mevalonate pathway and a defect in learning | 24-hydroxycholesterol + oxidized adrenodoxin + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
hippocampus | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + reduced adrenodoxin + O2 | - |
Mus musculus | 24-hydroxycholesterol + oxidized adrenodoxin + H2O | - |
? | |
cholesterol + reduced adrenodoxin + O2 | enzyme deficiency leads to a suppression of the mevalonate pathway and a defect in learning | Mus musculus | 24-hydroxycholesterol + oxidized adrenodoxin + H2O | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Mus musculus |