Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.14.25 extracted from

  • Pikuleva, I.A.
    Cholesterol-metabolizing cytochromes P450 (2006), Drug Metab. Dispos., 34, 513-520.
    View publication on PubMed
Search for more literature for 1.14.14.25

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0053
-
 cholesterol
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + NADPH + O2 Homo sapiens the enzyme is responsible for cholesterol elimination from brain, (24S)-hydroxycholesterol can cross the blood-brain barrier, enter the circulation, and then be delivered to the liver for further degradation, cholesterol metabolism, overview, CYP46A1 may participate in metabolism of neurosteroids and drugs that are targeted to the central nervous system (24S)-hydroxycholesterol + NADP+ + H2O
-
 ?
additional information Homo sapiens (24S)-hydroxycholesterol is a potent activator of the LXR receptor, CYP46A1-deficiency plays a role in the pathogenesis of this neurological disorder, such as Alzheimer's disease ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 = (24S)-cholest-5-ene-3beta,24-diol + [oxidized NADPH-hemoprotein reductase] + H2O structure-function relationship Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
brain specific Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(24S)-hydroxycholesterol + [reduced NADPH-hemoprotein reductase] + O2 preferred substrate in vitro Homo sapiens 24,25-dihydroxycholesterol + 24,27-dihydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
cholesterol + NADPH + O2
-
 Homo sapiens (24S)-hydroxycholesterol + NADP+ + H2O
-
 ?
cholesterol + NADPH + O2 the enzyme is responsible for cholesterol elimination from brain, (24S)-hydroxycholesterol can cross the blood-brain barrier, enter the circulation, and then be delivered to the liver for further degradation, cholesterol metabolism, overview, CYP46A1 may participate in metabolism of neurosteroids and drugs that are targeted to the central nervous system Homo sapiens (24S)-hydroxycholesterol + NADP+ + H2O
-
 ?
dextromethorphan + [reduced NADPH-hemoprotein reductase] + O2 O- and N-demethylation Homo sapiens ?
-
 ?
diclofenac + [reduced NADPH-hemoprotein reductase] + O2 4'-hydroxylation Homo sapiens ?
-
 ?
additional information (24S)-hydroxycholesterol is a potent activator of the LXR receptor, CYP46A1-deficiency plays a role in the pathogenesis of this neurological disorder, such as Alzheimer's disease Homo sapiens ?
-
 ?
additional information CYP46A1 shows broad substrate specificity Homo sapiens ?
-
 ?
phenacetin + [reduced NADPH-hemoprotein reductase] + O2 O-deethylation Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More structure-function relationship Homo sapiens

Synonyms

Synonyms Comment Organism
CYP46A1
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.11
-
 cholesterol
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens