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Literature summary for 1.14.14.25 extracted from

  • Brown, J.3rd.; Theisler, C.; Silberman, S.; Magnuson, D.; Gottardi-Littell, N.; Lee, J.M.; Yager, D.; Crowley, J.; Sambamurti, K.; Rahman, M.M.; Reiss, A.B.; Eckman, C.B.; Wolozin, B.
    Differential expression of cholesterol hydroxylases in Alzheimer's disease (2004), J. Biol. Chem., 279, 34674-34681.
    View publication on PubMed
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Application

Application Comment Organism
medicine CYP46A1 affects the pathophysiology of AD and provides insight into how polymorphisms in the CYP46A1 gene might influence the pathophysiology of this prevalent disease Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens CYP46A1 affects the pathophysiology of Alzheimers' disease and provides insight into how polymorphisms in the CYP46A1 gene might influence the pathophysiology of this prevalent disease ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
astrocyte in normal brain Homo sapiens
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brain in neurons and some astrocytes in the normal brain, in Alzheimer's disease the enzyme shows prominent expression in astrocytes and around amyloid plaques Homo sapiens
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neuron in normal brain Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information CYP46A1 affects the pathophysiology of Alzheimers' disease and provides insight into how polymorphisms in the CYP46A1 gene might influence the pathophysiology of this prevalent disease Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
CYP46A1
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 Homo sapiens