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Literature summary for 1.14.14.23 extracted from

  • Lammel Lindemann, J.A.; Angajala, A.; Engler, D.A.; Webb, P.; Ayers, S.D.
    Thyroid hormone induction of human cholesterol 7 alpha-hydroxylase (Cyp7a1) in vitro (2014), Mol. Cell. Endocrinol., 388, 32-40.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine manipulation of hormone signaling pathways can provide a strategy to enhance Cyp7a1 activity in human patients Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene Cyp7a1, enzyme expression analysis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P22680 gene CYP7A1
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-
hepatocyte
-
 Homo sapiens
-
liver
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
cholesterol 7 alpha-hydroxylase
-
 Homo sapiens
CYP7A1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens Cyp7a1 is a direct thyroid hormone target gene that responds to physiologic thyroid hormone levels through a set of distinct response elements in its promoter up

General Information

General Information Comment Organism
evolution the enzyme belongs to the cytochrome P450 family Homo sapiens
additional information thyroid hormones regulate cholesterol to bile acid conversion in similar ways in humans and rodent experimental models Homo sapiens
physiological function thyroid hormone modulates serum cholesterol by acting on thyroid hormone receptor beta1 in liver to regulate metabolic gene sets. One important thyroid hormone regulated step involves induction of Cyp7a1, an enzyme in the cytochrome P450 family, which enhances cholesterol to bile acid conversion and plays a crucial role in regulation of serum cholesterol levels Homo sapiens