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Literature summary for 1.14.14.23 extracted from

  • Fu, Z.D.; Cui, J.Y.; Klaassen, C.D.
    Atorvastatin induces bile acid-synthetic enzyme Cyp7a1 by suppressing FXR signaling in both liver and intestine in mice (2014), J. Lipid Res., 55, 2576-2586.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus Q64505
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Mus musculus C57BL/6 Q64505
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Source Tissue

Source Tissue Comment Organism Textmining
intestine
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Mus musculus
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liver
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Mus musculus
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Synonyms

Synonyms Comment Organism
bile acid-synthetic enzyme
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Mus musculus
cholesterol 7alpha-hydroxylase
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Mus musculus
CYP7A1
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Mus musculus

Expression

Organism Comment Expression
Mus musculus atorvastatin induces enzyme Cyp7a1 by suppressing FXR signaling in both liver and intestine. Atorvastatin suppresses the expression of bile acid nuclear receptor farnesoid X receptor (FXR) target genes, namely small heterodimer partner (liver) and fibroblast growth factor 15 (ileum). Atorvastatin increases the mRNAs of the organic cation uptake transporter 1 and cholesterol efflux transporters Abcg5 and Abcg8 in the liver up

General Information

General Information Comment Organism
metabolism Cyp7a1 is a bile acid-synthetic enzyme suppressed by FXR signaling in both liver and intestine in mice, bile acid profiling in untreated and bile acid-treated liver and intestine, overview Mus musculus