Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q64505 | - |
- |
Mus musculus C57BL/6 | Q64505 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intestine | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
bile acid-synthetic enzyme | - |
Mus musculus |
cholesterol 7alpha-hydroxylase | - |
Mus musculus |
CYP7A1 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | atorvastatin induces enzyme Cyp7a1 by suppressing FXR signaling in both liver and intestine. Atorvastatin suppresses the expression of bile acid nuclear receptor farnesoid X receptor (FXR) target genes, namely small heterodimer partner (liver) and fibroblast growth factor 15 (ileum). Atorvastatin increases the mRNAs of the organic cation uptake transporter 1 and cholesterol efflux transporters Abcg5 and Abcg8 in the liver | up |
General Information | Comment | Organism |
---|---|---|
metabolism | Cyp7a1 is a bile acid-synthetic enzyme suppressed by FXR signaling in both liver and intestine in mice, bile acid profiling in untreated and bile acid-treated liver and intestine, overview | Mus musculus |