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Literature summary for 1.14.14.23 extracted from
- Overexpression of cholesterol 7alpha-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis (2011), Hepatology, 53, 996-1006.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| Cyp7a1-tg mice overexpressing rat Cyp7a1 complementary DNA under an ApoE3 hepatic control region | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | P18125 | - |
- |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | transgenic mice overexpressing rat enzyme have 2fold higher isoform Cyp7a1 activity and bile acid pool than wild type mice. Gallbladder bile acid composition changes from predominantly cholic acid in wild type to chenodeoxycholic acid in trangenic mice. Transgenic mice have higher biliary and fecal cholesterol and bile acid secretion rates than wild type mice. Hepatic de novo cholesterol synthesis is markedly induced in trangenic mice but intestine fractional cholesterol absorption remains the same as wild type mice despite increased intestine bile acids. Hepatic but not intestinal expression of cholesterol transporters such as ABCG5/G8, SRB1 and bile acid transporters such as ABCB11 are significantly induced in transgenic mice | Rattus norvegicus |
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Release 2023.1 (January 2023)
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