Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.14.23 extracted from

  • Song, K.H.; Li, T.; Owsley, E.; Chiang, J.Y.
    A putative role of micro RNA in regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes (2010), J. Lipid Res., 51, 2223-2233.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
gene CYP7A1
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
Homo sapiens
-
hepatocyte
-
Homo sapiens
-
Huh-7 cell
-
Homo sapiens
-
liver
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
cholesterol 7alpha-hydroxylase
-
Homo sapiens
CYP7A1
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens bile acid-activated farnesoid X receptor, FXR, inhibits CYP7A1 transcription via activation of FGF15 receptor 4 signaling in hepatocytes, or via FGF19, that strongly inhibits CYP7A1 mRNA expression, overview. miR-122a and miR-422a may destabilize CYP7A1 mRNA to inhibit CYP7A1 expression, putative recognition sequences for miR-122a and miR-422a are localized in the 3'-UTR of human CYP7A1 mRNA down
Homo sapiens CYP7A1 mRNAs have very short half-lives, and bile acids destabilize CYP7A1 mRNA via the 3'-untranslated region additional information

General Information

General Information Comment Organism
physiological function cholesterol 7 alpha-hydroxylase plays a critical role in regulation of bile acid synthesis in the liver Homo sapiens