Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.14.23 extracted from

  • Shin, Y.; Vaziri, N.D.; Willekes, N.; Kim, C.H.; Joles, J.A.
    Effects of gender on hepatic HMG-CoA reductase, cholesterol 7alpha-hydroxylase, and LDL receptor in hereditary analbuminemia (2005), Am. J. Physiol. Endocrinol. Metab., 289, E993-E998.
    View publication on PubMed
Search for more literature for 1.14.14.23

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 Rattus norvegicus rate-limiting enzyme in cholesterol conversion to bile acids 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 Rattus norvegicus Sprague-Dawley rate-limiting enzyme in cholesterol conversion to bile acids 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
additional information Rattus norvegicus the sex difference in plasma cholesterol content diminishes after ovariectomy, hypercholesterolemia is more severe in the female than in the male Nagase analbuminemic rats, molecular mechanism ?
-
 ?
additional information Rattus norvegicus Sprague-Dawley the sex difference in plasma cholesterol content diminishes after ovariectomy, hypercholesterolemia is more severe in the female than in the male Nagase analbuminemic rats, molecular mechanism ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Sprague-Dawley and Nagase analbuminemic rats
-

Source Tissue

Source Tissue Comment Organism Textmining
liver effects of gender on hepatic enzyme activity, overview Rattus norvegicus
-
additional information enzyme activity in rats of different strains and with different sexes, the enzyme is upregulated in both female and male Nagase analbuminemic rats compared to Sprague-Dawley rats, overview Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 enzyme activity in rats of different strains and with different sexes, overview Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Rattus norvegicus 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 rate-limiting enzyme in cholesterol conversion to bile acids Rattus norvegicus 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Rattus norvegicus Sprague-Dawley 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 rate-limiting enzyme in cholesterol conversion to bile acids Rattus norvegicus Sprague-Dawley 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
additional information the sex difference in plasma cholesterol content diminishes after ovariectomy, hypercholesterolemia is more severe in the female than in the male Nagase analbuminemic rats, molecular mechanism Rattus norvegicus ?
-
 ?
additional information the sex difference in plasma cholesterol content diminishes after ovariectomy, hypercholesterolemia is more severe in the female than in the male Nagase analbuminemic rats, molecular mechanism Rattus norvegicus Sprague-Dawley ?
-
 ?

Synonyms

Synonyms Comment Organism
cholesterol 7alpha-hydroxylase
-
 Rattus norvegicus
CYP7A1
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Rattus norvegicus