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Literature summary for 1.14.14.19 extracted from

  • Simonov, A.N.; Holien, J.K.; Yeung, J.C.; Nguyen, A.D.; Corbin, C.J.; Zheng, J.; Kuznetsov, V.L.; Auchus, R.J.; Conley, A.J.; Bond, A.M.; Parker, M.W.; Rodgers, R.J.; Martin, L.L.
    Mechanistic scrutiny identifies a kinetic role for cytochrome b5 regulation of human cytochrome P450c17 (CYP17A1, P450 17A1) (2015), PLoS ONE, 10, e0141252 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens P05093
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-

Synonyms

Synonyms Comment Organism
P450c17
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 Homo sapiens

General Information

General Information Comment Organism
physiological function close interactions within living cells between cytochrome P450c17 and cytochrome b5. Residues E48 and E49 residues in cytochrome b5 are essential for activity. The wild type cytochrome b5, but not a mutated, E48G/E49G cyt b5, alters the kinetics of electron transfer between the electrode and the P450c17 during quartz crystal microbalance studies Homo sapiens