Literature summary for 1.14.14.19 extracted from

Yoshimoto, F.K.; Peng, H.M.; Zhang, H.; Anderson, S.M.; Auchus, R.J.
Epoxidation activities of human cytochromes P450c17 and P450c21 (2014), Biochemistry, 53, 7531-7540 .

Search for more literature for 1.14.14.19

Protein Variants

Protein Variants	Comment	Organism
A105L	mutant has reduced progesterone 16alpha-hydroxylase activity. Catalyzes the 16alpha,17-epoxidation and the ordinarily minor 21-hydroxylation of 16,17-dehydroprogesterone in a 1:5 ratio of epoxide:21-hydroxylated products	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P05093	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
16,17-dehydropregnenolone + [reduced NADPH-hemoprotein reductase] + O2	-	Homo sapiens	? + [oxidized NADPH-hemoprotein reductase] + H2O	-	?
16,17-dehydroprogesterone + [reduced NADPH-hemoprotein reductase] + O2	-	Homo sapiens	? + [oxidized NADPH-hemoprotein reductase] + H2O	-	?
additional information	CYP17A1 wild-type and mutation A105L do not hydroxylate pregnenolone in 21- or 16alpha-position	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
P450c17	-	Homo sapiens

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Release 2023.1 (January 2023)