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Literature summary for 1.14.14.19 extracted from

  • Ivanyi, Z.; Woelfling, J.; Goerbe, T.; Szecsi, M.; Wittmann, T.; Schneider, G.
    Synthesis of regioisomeric 17beta-N-phenylpyrazolyl steroid derivatives and their inhibitory effect on 17alpha-hydroxylase/C(17,20)-lyase (2010), Steroids, 75, 450-456.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
17beta-(1-p-chlorophenyl-3-pyrazolyl)androst-4-en-3-one
-
Rattus norvegicus
17beta-(1-p-chlorophenyl-3-pyrazolyl)androst-5-en-3beta-ol
-
Rattus norvegicus
17beta-(1-p-chlorophenyl-5-pyrazolyl)androst-4-en-3-one
-
Rattus norvegicus
17beta-(1-p-chlorophenyl-5-pyrazolyl)androst-5-en-3beta-ol
-
Rattus norvegicus
17beta-(1-p-cyanophenyl-3-pyrazolyl)androst-4-en-3-one
-
Rattus norvegicus
17beta-(1-p-cyanophenyl-3-pyrazolyl)androst-5-en-3beta-ol
-
Rattus norvegicus
17beta-(1-p-cyanophenyl-5-pyrazolyl)androst-4-en-3-one
-
Rattus norvegicus
17beta-(1-p-cyanophenyl-5-pyrazolyl)androst-5-en-3beta-ol
-
Rattus norvegicus
17beta-(1-p-methoxyphenyl-3-pyrazolyl)androst-4-en-3-one
-
Rattus norvegicus
17beta-(1-p-methoxyphenyl-3-pyrazolyl)androst-5-en-3beta-ol
-
Rattus norvegicus
17beta-(1-p-methoxyphenyl-5-pyrazolyl)androst-4-en-3-one
-
Rattus norvegicus
17beta-(1-p-methoxyphenyl-5-pyrazolyl)androst-5-en-3beta-ol
-
Rattus norvegicus
17beta-(1-p-tolyl-3-pyrazolyl)androst-4-en-3-one
-
Rattus norvegicus
17beta-(1-p-tolyl-5-pyrazolyl)androst-4-en-3-one
-
Rattus norvegicus
17beta-(1-p-tolylphenyl-3-pyrazolyl)androst-5-en-3beta-ol
-
Rattus norvegicus
17beta-(1-p-tolylphenyl-5-pyrazolyl)androst-5-en-3beta-ol
-
Rattus norvegicus
17beta-(1-phenyl-3-pyrazolyl)androst-4-en-3-one
-
Rattus norvegicus
17beta-(1-phenyl-3-pyrazolyl)androst-5-en-3beta-ol
-
Rattus norvegicus
17beta-(1-phenyl-5-pyrazolyl)androst-4-en-3-one
-
Rattus norvegicus
17beta-(1-phenyl-5-pyrazolyl)androst-5-en-3beta-ol
-
Rattus norvegicus
additional information inhibitory effects of synthesized 3beta-hydroxy-17beta-exo-heterocyclic steroids and the corresponding DELTA4-3-ketosteroids on the testicular C17,20-lyase activity are analyzed by an in vitro radioligand incubation technique, overview Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
17alpha-hydroxylase/C(17,20)-lyase
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.022
-
pH and temperature not specified in the publication Rattus norvegicus 17beta-(1-p-cyanophenyl-3-pyrazolyl)androst-4-en-3-one
0.059
-
pH and temperature not specified in the publication Rattus norvegicus 17beta-(1-phenyl-5-pyrazolyl)androst-4-en-3-one