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Literature summary for 1.14.14.19 extracted from

  • Pattison, J.C.; Saltzman, W.; Abbott, D.H.; Hogan, B.K.; Nguyen, A.D.; Husen, B.; Einspanier, A.; Conley, A.J.; Bird, I.M.
    Gender and gonadal status differences in zona reticularis expression in marmoset monkey adrenals: Cytochrome b5 localization with respect to cytochrome P450 17,20-lyase activity (2007), Mol. Cell. Endocrinol., 265-266, 93-101.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
co-expression of CYP17 and NADPH-P450 reductase in Escherichia coli, expression of the enzyme in insect cells via baculovirus transfection Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-(1-(4-thiophen-3-yl-phenyl)ethyl)-1H-imidazole
-
 Rattus norvegicus
1-(1-(4-thiophen-3-yl-phenyl)propyl)-1H-imidazole
-
 Rattus norvegicus
1-(1-[4-[5-(methylsulfanyl)thiophen-2-yl]phenyl]propyl)-1H-imidazole
-
 Homo sapiens
1-(1H-imidazol-5-yl)-2-methyl-1-(4-thiophen-3-ylphenyl)propan-1-ol
-
 Homo sapiens
1-(4-furan-3-ylbenzyl)-1H-imidazole
-
 Homo sapiens
1-[(4-phenylthiophen-2-yl)methyl]-1H-imidazole
-
 Homo sapiens
1-[1-(4-thiophen-3-ylphenyl)ethyl]-1H-imidazole
-
 Homo sapiens
1-[1-(4-thiophen-3-ylphenyl)propyl]-1H-imidazole
-
 Homo sapiens
1-[1-[2-fluoro-4-(4-methylthiophen-3-yl)phenyl]propyl]-1H-imidazole
-
 Homo sapiens
1-[1-[4-(2-chlorothiophen-3-yl)phenyl]propyl]-1H-imidazole
-
 Homo sapiens
1-[1-[4-(3,4-difluorophenyl)thiophen-2-yl]propyl]-1H-imidazole
-
 Homo sapiens
1-[1-[4-(4-methylthiophen-3-yl)phenyl]propyl]-1H-imidazole
-
 Homo sapiens
1-[4-(4-methylthiophen-3-yl)benzyl]-1H-imidazole
-
 Homo sapiens
1-[4-[5-(methylsulfanyl)thiophen-2-yl]benzyl]-1H-imidazole
-
 Homo sapiens
1-[[4-(3,4-difluorophenyl)thiophen-2-yl]methyl]-1H-imidazole
-
 Homo sapiens
1-[[4-(3,4-dimethoxyphenyl)thiophen-2-yl]methyl]-1H-imidazole
-
 Homo sapiens
1-[[4-(3-methoxyphenyl)thiophen-2-yl]methyl]-1H-imidazole
-
 Homo sapiens
1-[[4-(4-fluorophenyl)thiophen-2-yl]methyl]-1H-imidazole
-
 Homo sapiens
1-[[4-(4-methoxyphenyl)thiophen-2-yl]methyl]-1H-imidazole
-
 Homo sapiens
2-(chloromethyl)-5-[4-(1H-imidazol-1-ylmethyl)phenyl]pyridine
-
 Homo sapiens
2-fluoro-5-[4-(1H-imidazol-1-ylmethyl)phenyl]pyridine
-
 Homo sapiens
3-[4-(1H-imidazol-1-ylmethyl)phenyl]pyridine
-
 Homo sapiens
4-[4-[1-(1H-imidazol-1-yl)ethyl]phenyl]morpholine
-
 Homo sapiens
5-[4-(1H-imidazol-1-ylmethyl)phenyl]pyrimidine
-
 Homo sapiens
abiraterone
-
 Homo sapiens
abiraterone
-
 Rattus norvegicus
ketoconazole
-
 Homo sapiens
additional information synthesis and inhibitory potency of inhibitors, inhibitor molecular modelling studies, ligand binding modes, overview Homo sapiens
additional information synthesis and inhibitory potency of inhibitors, overview Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-
microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pregnenolone + AH2 + O2 Homo sapiens
-
 17alpha-hydroxypregnenolone + A + H2O
-
 ?
pregnenolone + AH2 + O2 Rattus norvegicus
-
 17alpha-hydroxypregnenolone + A + H2O
-
 ?
progesterone + AH2 + O2 Homo sapiens
-
 17alpha-hydroxyprogesterone + A + H2O
-
 ?
progesterone + AH2 + O2 Rattus norvegicus
-
 17alpha-hydroxyprogesterone + A + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pregnenolone + AH2 + O2
-
 Homo sapiens 17alpha-hydroxypregnenolone + A + H2O
-
 ?
pregnenolone + AH2 + O2
-
 Rattus norvegicus 17alpha-hydroxypregnenolone + A + H2O
-
 ?
progesterone + AH2 + O2
-
 Homo sapiens 17alpha-hydroxyprogesterone + A + H2O
-
 ?
progesterone + AH2 + O2
-
 Rattus norvegicus 17alpha-hydroxyprogesterone + A + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYP17
-
 Homo sapiens
CYP17
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000072
-
-
 Homo sapiens abiraterone
0.00022
-
-
 Rattus norvegicus abiraterone
0.00278
-
-
 Homo sapiens ketoconazole