Literature summary for 1.14.14.19 extracted from

Naffin-Olivos, J.L.; Auchus, R.J.
Human cytochrome b5 requires residues E48 and E49 to stimulate the 17,20-lyase activity of cytochrome P450c17 (2006), Biochemistry, 45, 755-762.

Activating Compound

Activating Compound	Comment	Organism	Structure
cytochrome b5	specific stimulation of 17,20-lyase activity of enzyme, up to 10fold increase in lyase activity, while 17alpha-hydroxylase activity is little affected	Homo sapiens

Organism	UniProt	Comment	Textmining
Homo sapiens	-	bifunctional 17alpha-hydroxylase and 17,20-lyase in steroid biosynthesis	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)