Application | Comment | Organism |
---|---|---|
medicine | inhibition of steroid 17alpha-monooxygenase is an important therapeutic strategy in order to inhibit tumor growth in prostate cancer | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
17-(1H-imidazol-1-yl)androsta-4,16-dien-3-one | - |
Homo sapiens | |
17-(1H-imidazol-1-yl)androsta-4,16-dien-3-one | - |
Rattus norvegicus | |
17-(2-amino-4-thiazolyl)-androsta-5,16-dien-3beta-ol | type II competitive inhibitor | Macacine alphaherpesvirus 1 | |
17-(3'-pyrazolyl)androsta-4,16-dien-3beta-one | type II competitive inhibitor | Homo sapiens | |
17-(3'-pyrazolyl)androsta-4,16-dien-3beta-one | type II competitive inhibitor | Rattus norvegicus | |
17-(3'-pyrazolyl)androsta-5,16-dien-3beta-ol | type II competitive inhibitor | Homo sapiens | |
17-(3'-pyrazolyl)androsta-5,16-dien-3beta-ol | type II competitive inhibitor | Rattus norvegicus | |
17-(3-pyridyl)androsta-5,6-dien-3beta-ol | - |
Homo sapiens | |
17-(5'-isooxazoloyl)androsta-4,16-dien-3-one | type II competitive inhibitor | Homo sapiens | |
17-(5'-isooxazoloyl)androsta-4,16-dien-3-one | type II competitive inhibitor | Rattus norvegicus | |
17-(methylthio)androst-5-en-3beta-ol S-oxide | type I competitive inhibitor | Sus scrofa | |
17beta-acetamidoandrost-4-en-3-one | - |
Homo sapiens | |
17beta-ureidoandrosta-1,4-dien-3-one | - |
Homo sapiens | |
2-(1H-imidazol-4-ylmethyl)-9H-carbazole | suicide inhibitor | Rattus norvegicus | |
20(S)-20,21-aziridinylpregn-5-en-3beta-ol | type II competitive inhibitor | Rattus norvegicus | |
20xi-hydroxy-21-trifluoropregn-4-en-3-one | type I competitive inhibitor | Rattus norvegicus | |
3-pyridyl-1a,2,3,7b-tetrahydro-1H-cyclopropa[a]naphthalene | suicide inhibitor | Rattus norvegicus | |
3beta-hydroxy-17-(1H-1,2,3-triazol-1-yl)androsta-5,16-diene | type II competitive inhibitor | Homo sapiens | |
3beta-hydroxy-17-(1H-imidazol-1-yl)androsta-5,16-diene | type II competitive inhibitor | Homo sapiens | |
4-amino-17beta-(cyclopropylamino)-androst-4-en-3-one | suicide inhibitor | Macacine alphaherpesvirus 1 | |
4-amino-17beta-(cyclopropyloxy)-androst-4,6-dien-3-one | suicide inhibitor | Macacine alphaherpesvirus 1 | |
4-amino-17beta-(cyclopropyloxy)-androst-4-en-3-one | suicide inhibitor | Macacine alphaherpesvirus 1 | |
5-[(3-chlorophenyl-1H-imidazole-1-yl)methyl]-1H-benzimidazole | suicide inhibitor | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pregnenolone + AH2 + O2 | Homo sapiens | - |
17alpha-hydroxypregnenolone + A + H2O | - |
? | |
pregnenolone + AH2 + O2 | Rattus norvegicus | - |
17alpha-hydroxypregnenolone + A + H2O | - |
? | |
pregnenolone + AH2 + O2 | Sus scrofa | - |
17alpha-hydroxypregnenolone + A + H2O | - |
? | |
progesterone + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | - |
17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? | |
progesterone + [reduced NADPH-hemoprotein reductase] + O2 | Rattus norvegicus | - |
17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? | |
progesterone + [reduced NADPH-hemoprotein reductase] + O2 | Sus scrofa | - |
17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Macacine alphaherpesvirus 1 | - |
cynomolgus monkey | - |
Rattus norvegicus | - |
- |
- |
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
testis | - |
Rattus norvegicus | - |
testis | - |
Sus scrofa | - |
testis | adult and foetal | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pregnenolone + AH2 + O2 | - |
Homo sapiens | 17alpha-hydroxypregnenolone + A + H2O | - |
? | |
pregnenolone + AH2 + O2 | - |
Rattus norvegicus | 17alpha-hydroxypregnenolone + A + H2O | - |
? | |
pregnenolone + AH2 + O2 | - |
Sus scrofa | 17alpha-hydroxypregnenolone + A + H2O | - |
? | |
progesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? | |
progesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? | |
progesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Sus scrofa | 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
34 | - |
- |
Homo sapiens |
34 | - |
- |
Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens | |
NADPH | - |
Rattus norvegicus | |
NADPH | - |
Sus scrofa |