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Literature summary for 1.14.14.180 extracted from

  • Kim, T.W.; Hwang, J.Y.; Kim, Y.S.; Joo, S.H.; Chang, S.C.; Lee, J.S.; Takatsuto, S.; Kim, S.K.
    Arabidopsis CYP85A2, a cytochrome P450, mediates the Baeyer-Villiger oxidation of castasterone to brassinolide in brassinosteroid biosynthesis (2005), Plant Cell, 17, 2397-2412 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression in yeast Arabidopsis thaliana

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q940V4 bifunctional enzyme, possesses brassinosteroid C-6 oxidase and brassinolide synthase activity, reactions of ECs 1.14.14.179 and 1.14.14.180
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
castasterone + O2 + [reduced NADPH-hemoprotein reductase]
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 Arabidopsis thaliana brassinolide + 2 H2O + [oxidized NADPH-hemoprotein reductase]
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 ?

Synonyms

Synonyms Comment Organism
BR6OX2
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 Arabidopsis thaliana
CYP85A2
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 Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
cytochrome P450
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 Arabidopsis thaliana

General Information

General Information Comment Organism
physiological function enzyme is a cytochrome P450 that mediates Baeyer-Villiger oxidation in plants. Castasterone isa bioactive brassinosteroid that controls the overall growth and development of Arabidopsis plants. Mutant studies also revealed that brassinolide may not always be necessary for normal growth and development but Arabidopsis plants acquire great benefit in terms of growth and development in the presence of brassinolide Arabidopsis thaliana