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Literature summary for 1.14.14.18 extracted from

  • Andrade, B.B.; Pavan Kumar, N.; Mayer-Barber, K.D.; Barber, D.L.; Sridhar, R.; Rekha, V.V.; Jawahar, M.S.; Nutman, T.B.; Sher, A.; Babu, S.
    Plasma heme oxygenase-1 levels distinguish latent or successfully treated human tuberculosis from active disease (2013), PLoS ONE, 8, e62618.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine the enzyme is a potentially useful parameter for distinguishing active from latent or treated pulmonary tuberculosis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protoheme + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 biliverdin + Fe2+ + CO + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protoheme + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens biliverdin + Fe2+ + CO + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
heme oxygenase-1
-
 Homo sapiens
HO-1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens systemic enzyme levels are dramatically increased in individuals with active pulmonary and extra-pulmonary tuberculosis and particularly those with bilateral lung lesions and elevated bacillary loads in sputum up