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Literature summary for 1.14.14.18 extracted from

  • Rousset, F.; Nguyen, M.V.; Grange, L.; Morel, F.; Lardy, B.
    Heme oxygenase-1 regulates matrix metalloproteinase MMP-1 secretion and chondrocyte cell death via Nox4 NADPH oxidase activity in chondrocytes (2013), PLoS ONE, 8, e66478.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine modulation of Nox4 activity via heme oxygenase-1 may represent a promising therapeutic tool in osteoarthritis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P09601
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-

Source Tissue

Source Tissue Comment Organism Textmining
C-20/A4 cell
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 Homo sapiens
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chondrocyte
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 Homo sapiens
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HEK-293T cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
heme oxygenase-1
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 Homo sapiens
HO-1
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 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens HO-1 expression is chemically induced by cobalt protoporphyrin-IX in HEK293 T-RExTM Nox4 cells resulting in downregulation of NADPH oxidase Nox4 activity up

General Information

General Information Comment Organism
physiological function heme oxygenase-1 is the limiting enzyme in heme catabolism. Induction of HO-1 expression decreases dramatically NADPH oxidase Nox4 activity in C-20/A4 and HEK-293T-RExTM Nox4 cell lines, mediated by carbon monoxide, the decrease is not accompanied by any change in the expression, the subcellular localization or the maturation of Nox4. Inhibition of the heme synthesis by succinylacetone rather than heme catabolism by HO-1, leads to a confinement of the Nox4/p22phox heterodimer in the endoplasmic reticulum with an absence of redox differential spectrum highlighting an incomplete maturation. HO-1 decreases MMP-1 expression and chondrocytes DNA fragmentation via CO release Homo sapiens