Literature summary for 1.14.14.18 extracted from

Ishikado, A.; Nishio, Y.; Morino, K.; Ugi, S.; Kondo, H.; Makino, T.; Kashiwagi, A.; Maegawa, H.
Low concentration of 4-hydroxy hexenal increases heme oxygenase-1 expression through activation of Nrf2 and antioxidative activity in vascular endothelial cells (2010), Biochem. Biophys. Res. Commun., 402, 99-104.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
umbilical vein endothelial cell	HUVECs	Homo sapiens	-
vascular endothelial cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
heme oxygenase-1	-	Homo sapiens
HO-1	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	low concentration of 4-hydroxy hexenal increases heme oxygenase-1 expression through activation of Nrf2 and antioxidative activity in vascular endothelial cells, overview. The induction is abolished by knockout of Nrf2	up

General Information

General Information	Comment	Organism
physiological function	4-hydroxy hexenal stimulates expression of the antioxidant enzyme HO-1 through the activation of Nrf2 in vascular endothelial cells resulting in prevention of oxidative stress-induced cytotoxicity, this may represent a possible mechanism to partly explain the cardioprotective effects of n-3 polyunsaturated fatty acids	Homo sapiens

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Release 2023.1 (January 2023)