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Literature summary for 1.14.14.18 extracted from

  • Chen-Roetling, J.; Li, Z.; Chen, M.; Awe, O.O.; Regan, R.F.
    Heme oxygenase activity and hemoglobin neurotoxicity are attenuated by inhibitors of the MEK/ERK pathway (2009), Neuropharmacology, 56, 922-928.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine reduction in HO activity may contribute to the protective effect of MEK and ERK inhibitors against heme-mediated neuronal injury Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
FR180204 ERK inhibitor, reduces baseline culture HO activity, without altering the activity of recombinant HO-1 or HO-2 Mus musculus
SL327 MEK inhibitor, reduces baseline culture HO activity, without altering the activity of recombinant HO-1 or HO-2 Mus musculus
U0126 MEK inhibitor, reduces baseline culture HO activity, without altering the activity of recombinant HO-1 or HO-2 Mus musculus
zinc protoporphyrin IX activity of both recombinant isoenzymes HO-1 and HO-2 is strongly inhibited Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 fetal B6129 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
glial cell line
-
 Mus musculus
-
neuron
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
heme oxygenase
-
 Mus musculus
HO-1
-
 Mus musculus
HO-2
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus HO-1 induction after hemoglobin treatment is decreased by about half by MEK inhibitors U0126 and SL327, and is completely prevented by the direct ERK inhibitor FR180204 down
Mus musculus HO-1 induction by hemoglobin. In cultures treated with hemoglobin plus dimethylsulfoxide vehicle for 4 h, which is a time point prior to the onset of neuronal lysis, HO-1 expression is increased 2.2fold over control cultures treated with vehicle only up