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Literature summary for 1.14.14.18 extracted from

  • Hu, C.M.; Liu, Y.H.; Cheah, K.P.; Li, J.S.; Lam, C.S.; Yu, W.Y.; Choy, C.S.
    Heme oxygenase-1 mediates the inhibitory actions of brazilin in RAW264.7 macrophages stimulated with lipopolysaccharide (2009), J. Ethnopharmacol., 121, 79-85.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
brazilin main constituent of Caesalpinia sappan, induces HO-1 expression in a concentration-dependent manner at 0.01-0.3 mM at the level of protein synthesis, thus without affecting mRNA transcription of HO-1 Mus musculus
heme
-
Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
Zn(II) protoporphyrin IX mitigates brazilin-induced activity of HO-1 and inhibition of NO, PEG2, TNF-alpha and IL-1beta production in lipopolysaccharide-stimulated RAW264.7 macrophages Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
RAW-264.7 cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme + electron donor + O2
-
Mus musculus biliverdin + Fe2+ + CO + oxidized eletron donor + H2O
-
?

Synonyms

Synonyms Comment Organism
heme oxygenase-1
-
Mus musculus
HO-1
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
heme
-
Mus musculus