Activating Compound | Comment | Organism | Structure |
---|---|---|---|
brazilin | main constituent of Caesalpinia sappan, induces HO-1 expression in a concentration-dependent manner at 0.01-0.3 mM at the level of protein synthesis, thus without affecting mRNA transcription of HO-1 | Mus musculus | |
heme | - |
Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Zn(II) protoporphyrin IX | mitigates brazilin-induced activity of HO-1 and inhibition of NO, PEG2, TNF-alpha and IL-1beta production in lipopolysaccharide-stimulated RAW264.7 macrophages | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
RAW-264.7 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + electron donor + O2 | - |
Mus musculus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
heme oxygenase-1 | - |
Mus musculus |
HO-1 | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Mus musculus |