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Literature summary for 1.14.14.18 extracted from

  • Li, X.Y.; Zhang, C.; Wang, S.F.; Ji, Y.L.; Wang, H.; Zhao, L.; Xu, D.X.
    Maternally administered lipopolysaccharide (LPS) upregulates the expression of heme oxygenase-1 in fetal liver: the role of reactive oxygen species (2008), Toxicol. Lett., 176, 169-177.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
additional information lipopolysaccharide, from Escherichia coli, serotype 0127:B8, upregulates the expression of HO-1 in adult and fetal mouse liver, maternal LPS exposure results in oxidative stress in fetuses, which may contribute to LPS-induced developmental toxicity, LPS-induced upregulation of HO-1 is blocked by alpha-phenyl-N-t-butylnitrone, PBN, a free radical spin trapping agent, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
heme + AH2 + O2 Mus musculus HO-1 is an inducible enzyme that catalyzes the rate-limiting step in the degradation of heme to biliverdin, CO and iron biliverdin + Fe2+ + CO + A + H2O
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P14901 ICR, CD-1, mice
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Source Tissue

Source Tissue Comment Organism Textmining
liver
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme + AH2 + O2
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 Mus musculus biliverdin + Fe2+ + CO + A + H2O
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 ?
heme + AH2 + O2 HO-1 is an inducible enzyme that catalyzes the rate-limiting step in the degradation of heme to biliverdin, CO and iron Mus musculus biliverdin + Fe2+ + CO + A + H2O
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 ?

Synonyms

Synonyms Comment Organism
heme oxygenase-1
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 Mus musculus
HO-1
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 Mus musculus