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Literature summary for 1.14.14.18 extracted from

  • Gong, Q.; Yin, H.; Fang, M.; Xiang, Y.; Yuan, C.L.; Zheng, G.Y.; Yang, H.; Xiong, P.; Chen, G.; Gong, F.L.; Zheng, F.
    Heme oxygenase-1 upregulation significantly inhibits TNF-alpha and Hmgb1 releasing and attenuates lipopolysaccharide-induced acute lung injury in mice (2008), Int. Immunopharmacol., 8, 792-798.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information cobalt protoporphyrin, CoPPIX, induces HO-1 Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
zinc-protoporphyrin ZnPPIX Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
heme + AH2 + O2 Mus musculus heme oxygenase-1 upregulation significantly inhibits TNF-alpha and Hmgb1 releasing and attenuates lipopolysaccharide-induced acute lung injury in mice, overview biliverdin + Fe2+ + CO + A + H2O
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus P14901 male BALB/c mice
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
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Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme + AH2 + O2
-
Mus musculus biliverdin + Fe2+ + CO + A + H2O
-
?
heme + AH2 + O2 heme oxygenase-1 upregulation significantly inhibits TNF-alpha and Hmgb1 releasing and attenuates lipopolysaccharide-induced acute lung injury in mice, overview Mus musculus biliverdin + Fe2+ + CO + A + H2O
-
?

Synonyms

Synonyms Comment Organism
heme oxygenase-1
-
Mus musculus
HO-1
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Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus