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Literature summary for 1.14.14.18 extracted from

  • Lin, Q.S.; Weis, S.; Yang, G.; Zhuang, T.; Abate, A.; Dennery, P.A.
    Catalytic inactive heme oxygenase-1 protein regulates its own expression in oxidative stress (2008), Free Radic. Biol. Med., 44, 847-855.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information HO-1 is inducible in response to a variety of chemical and physical stress conditions to function as a cytoprotective molecule, hemin and cadmium chloride-mediated HO-1 induction, overview Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expression of GST-tagged wild-type and mutant enzymes in Escherichia coli strain BL21(DE3), transfection of wild-type HO-1 cDNA or intracellular delivery of pure HO-1 protein into cultured NIH 3T3 cells results in activation of a 15-kb HO-1 promoter independently of HO activity, expression of an catalytically inactive HO-1 also results in promoter activation, HO-1-mediated promoter activation is regulated via the distal enhancers E1 and E2 Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information HO-1-specific siRNA significantly reduces hemin and cadmium chloride-mediated HO-1 induction, cobstruction of HO-1 deletion mutants showing decreased enzyme activity Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
tin protoporphyrin SnPP Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32000
-
x * 32000, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
heme + AH2 + O2 Rattus norvegicus heme oxygenase is the rate-limiting enzyme in heme degradation to biliverdin, heme oxygenase-1 catalyzes the degradation of heme and forms antioxidant bile pigments as well as the signaling molecule carbon monoxide, HO-1 is inducible in response to a variety of chemical and physical stress conditions to function as a cytoprotective molecule. Catalytic inactive heme oxygenase-1 deletion mutant protein regulates its own expression in oxidative stress in a positive feedback manner, feed-forward autoregulation of HO-1 in oxidative stress, overview, HO-1 protein also plays a role in regulating cadmium chloride-mediated HO-1 gene induction biliverdin + Fe2+ + CO + A + H2O
-
?
additional information Rattus norvegicus HO-1 regulation, HO-1 autoregulation, and HO-1 regulatory functions, activation of MAPK pathways is not required in HO-1 self-regulation, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P06762
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme + AH2 + O2
-
Rattus norvegicus biliverdin + Fe2+ + CO + A + H2O
-
?
heme + AH2 + O2 heme oxygenase is the rate-limiting enzyme in heme degradation to biliverdin, heme oxygenase-1 catalyzes the degradation of heme and forms antioxidant bile pigments as well as the signaling molecule carbon monoxide, HO-1 is inducible in response to a variety of chemical and physical stress conditions to function as a cytoprotective molecule. Catalytic inactive heme oxygenase-1 deletion mutant protein regulates its own expression in oxidative stress in a positive feedback manner, feed-forward autoregulation of HO-1 in oxidative stress, overview, HO-1 protein also plays a role in regulating cadmium chloride-mediated HO-1 gene induction Rattus norvegicus biliverdin + Fe2+ + CO + A + H2O
-
?
additional information HO-1 regulation, HO-1 autoregulation, and HO-1 regulatory functions, activation of MAPK pathways is not required in HO-1 self-regulation, overview Rattus norvegicus ?
-
?

Subunits

Subunits Comment Organism
? x * 32000, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
heme oxygenase-1
-
Rattus norvegicus
HO-1
-
Rattus norvegicus