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Literature summary for 1.14.14.18 extracted from

  • Horvath, K.; Varga, C.; Berko, A.; Posa, A.; Laszlo, F.; Whittle, B.J.
    The involvement of heme oxygenase-1 activity in the therapeutic actions of 5-aminosalicylic acid in rat colitis (2008), Eur. J. Pharmacol., 581, 315-323.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
2,4,6-Trinitrobenzene sulfonic acid induces HO-1 expression in the colon and stimulates its catalytic activity Rattus norvegicus
5-aminosalicylic acid induces HO-1 expression in the colon and stimulates its catalytic activity Rattus norvegicus
additional information HO-1 is a heat shock protein with anti-inflammatory activity Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
zinc protoporphyrin ZnPP, supresses enzyme induction and inhibits HO-1, it also abolishes the anti-colitic effect of 5-aminosalicylic acid Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
heme + AH2 + O2 Rattus norvegicus HO-1 is a heat shock protein, and it provides endogenous anti-oxidant and anti-inflammatory moieties which can modulate colonic inflammation biliverdin + Fe2+ + CO + A + H2O
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P06762 male Wistar rats
-

Source Tissue

Source Tissue Comment Organism Textmining
colon
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme + AH2 + O2
-
Rattus norvegicus biliverdin + Fe2+ + CO + A + H2O
-
?
heme + AH2 + O2 HO-1 is a heat shock protein, and it provides endogenous anti-oxidant and anti-inflammatory moieties which can modulate colonic inflammation Rattus norvegicus biliverdin + Fe2+ + CO + A + H2O
-
?

Synonyms

Synonyms Comment Organism
heme oxygenase-1
-
Rattus norvegicus
HO-1
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Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Rattus norvegicus