Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | HO-1 expression, prooxidative activity, and cytotoxicity are increased after treatment with heme, heavy metals, and peroxides compared to control cells | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + AH2 + O2 | Homo sapiens | - |
biliverdin + Fe2+ + CO + A + H2O | - |
? | |
additional information | Homo sapiens | expression of Hepatitis C virus core protein sensitizes hepatocytes to toxic injury and inhibits the induction of HO-1 in response to stress, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P09601 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | Hep-G2 cell line C34 | Homo sapiens | - |
hepatocyte | HCV-infected liver biopsies and core protein-expressing hepatocytes show diminished levels of heme oxygenase-1 | Homo sapiens | - |
Huh-7 cell | - |
Homo sapiens | - |
liver | HO-1 is expressed primarily in Kupffer cells, HCV-infected liver biopsies and core protein-expressing hepatocytes show diminished levels of heme oxygenase-1 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + AH2 + O2 | - |
Homo sapiens | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
additional information | expression of Hepatitis C virus core protein sensitizes hepatocytes to toxic injury and inhibits the induction of HO-1 in response to stress, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
heme oxygenase-1 | - |
Homo sapiens |
HO-1 | - |
Homo sapiens |