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Literature summary for 1.14.14.18 extracted from
- Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice (2008), BMC Cancer, 8, 197.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| overexpression of HO-1 in B16F10 melanoma cells | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | knock-down of HO-1 expression by siRNA expression, overexpression of HO-1 in B16F10 cells confers resistance to cisplatin treatment, overview | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| zinc protoporphyrin IX | Zn(II)PPIX, a selective HO-1 inhibitor, Zn(II)PPIX exerts dose-dependent antitumor effects and shows retardation of tumor growth | Homo sapiens | |
| zinc protoporphyrin IX | Zn(II)PPIX, a selective HO-1 inhibitor, Zn(II)PPIX exerts dose-dependent antitumor effects and shows retardation of tumor growth | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| heme + AH2 + O2 | Homo sapiens | HO-1 participates in the degradation of heme, the enzyme is involved in tumor development | biliverdin + Fe2+ + CO + A + H2O | - |
? |  |
| heme + AH2 + O2 | Mus musculus | HO-1 participates in the degradation of heme, the enzyme is involved in tumor development | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
| additional information | Mus musculus | overexpression of HO-1 in B16F10 cells confers resistance to cisplatin treatment, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P09601 | - |
- |
| Mus musculus | P14901 | female BALB/c and C57Bl/6 mice | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| B16-F10 cell | - |
Mus musculus | - |
| breast adenocarcinoma cell | - |
Mus musculus | - |
| cavernous artery | - |
Mus musculus | - |
| Colon-26 cell | - |
Mus musculus | - |
| colonic adenocarcinoma cell | - |
Mus musculus | - |
| EMT-6 cell | - |
Mus musculus | - |
| MDA-MB-231 cell | a breast carcinoma | Homo sapiens | - |
| MDAH-2774 cell | an ovarian carcinoma cell line | Homo sapiens | - |
| melanoma cell | - |
Mus musculus | - |
| MiaPaCa-2 cell | a pancreatic cancer cell line | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| heme + AH2 + O2 | - |
Homo sapiens | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
| heme + AH2 + O2 | - |
Mus musculus | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
| heme + AH2 + O2 | HO-1 participates in the degradation of heme, the enzyme is involved in tumor development | Homo sapiens | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
| heme + AH2 + O2 | HO-1 participates in the degradation of heme, the enzyme is involved in tumor development | Mus musculus | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
| additional information | overexpression of HO-1 in B16F10 cells confers resistance to cisplatin treatment, overview | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| heme oxygenase-1 | - |
Homo sapiens |
| heme oxygenase-1 | - |
Mus musculus |
| HO-1 | - |
Homo sapiens |
| HO-1 | - |
Mus musculus |
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