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Literature summary for 1.14.14.18 extracted from
- Tranilast, an orally active anti-allergic drug, up-regulates the anti-inflammatory heme oxygenase-1 expression but down-regulates the pro-inflammatory cyclooxygenase-2 and inducible nitric oxide synthase expression in RAW264.7 macrophages (2008), Biochem. Biophys. Res. Commun., 371, 361-365.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | tranilast, i.e. N-[3',4'-dimethoxycinnamonyl] anthranilic acid, an orally active anti-allergic drug, tranilast induces heme oxygenase-1 expression through the extracellular signal-regulated kinase-1/2 pathway in RAW264.7 macrophages. Effects of tranilast on LPS-induced PGE2, NO, TNF-alpha, and IL-1beta production are partially reversed by the HO-1 inhibitor tin protoporphyrin, overview. UO126 significantly inhibits tranilast-induced HO-1 expression, but neither SB203580 nor SP600125 have a significant effect on HO-1 expression by tranilast | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| heme + AH2 + O2 | Mus musculus | the enzyme shows anti-inflammatory activity, HO-1 expression is induced via the ERK1/2 activation pathway | biliverdin + Fe2+ + CO + A + H2O | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | P14901 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| macrophage | - |
Mus musculus | - |
| RAW-264.7 cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| heme + AH2 + O2 | - |
Mus musculus | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
| heme + AH2 + O2 | the enzyme shows anti-inflammatory activity, HO-1 expression is induced via the ERK1/2 activation pathway | Mus musculus | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| heme oxygenase-1 | - |
Mus musculus |
| HO-1 | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Mus musculus |
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