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Literature summary for 1.14.14.18 extracted from

  • Furci, L.M.; Lopes, P.; Eakanunkul, S.; Zhong, S.; MacKerell, A.D.; Wilks, A.
    Inhibition of the bacterial heme oxygenases from Pseudomonas aeruginosa and Neisseria meningitidis: novel antimicrobial targets (2007), J. Med. Chem., 50, 3804-3813.
    View publication on PubMed
Search for more literature for 1.14.14.18

Application

Application Comment Organism
drug development the enzyme is a potential therapeutic target for antimicrobial drug development, computer-aided drug design and screening, overview Neisseria meningitidis

Inhibitors

Inhibitors Comment Organism Structure
(2E)-2-[4-(dimethylamino)benzylidene]hydrazinecarboximidamide binding affinity 0.0229 mM, inhibition of biliverdin production in Escherichia coli expressing the enzyme Neisseria meningitidis
(2E)-2-[[4-(dimethylamino)phenyl]methylidene]hydrazinecarboximidamide binding affinity is 0.0229 mM, complete inhibition Neisseria meningitidis
(2Z)-4-[(4-anilinophenyl)amino]-4-oxobut-2-enoic acid binding affinity 0.0156 mM, inhibition of biliverdin production in Escherichia coli expressing the enzyme Neisseria meningitidis
(2Z)-N'-[(1Z)-pyridin-3-ylmethylene]-2-(pyridin-3-ylmethylene)hydrazinecarboximidohydrazide binding affinity 0.0122 mM, inhibition of biliverdin production in Escherichia coli expressing the enzyme Neisseria meningitidis
(2Z)-N'-[(1Z)-pyridin-3-ylmethylidene]-2-(pyridin-3-ylmethylidene)hydrazinecarboximidohydrazide binding affinity is 0.0122 mM, complete inhibition Neisseria meningitidis
1-(2,4-dinitrophenyl)methanamine binding affinity 0.239 mM Neisseria meningitidis
2-(4-chlorophenyl)-N'-[(1E)-1H-indol-3-ylmethylidene]acetohydrazide binding affinity is 0.0141 mM, complete inhibition Neisseria meningitidis
2-(4-chlorophenyl)-N'-[(1Z)-1H-inden-3-ylmethylene]acetohydrazide binding affinity 0.0141 mM, inhibition of biliverdin production in Escherichia coli expressing the enzyme Neisseria meningitidis
4-oxo-4-[[4-(phenylamino)phenyl]amino]butanoic acid binding affinity is 0.0156 mM, complete inhibition Neisseria meningitidis
4-[(2-hydroxyphenyl)amino]naphthalene-1,2-dione binding affinity is 0.0288 mM, partial inhibition Neisseria meningitidis
N'-(pyridin-4-ylcarbonyl)pyridine-4-carbohydrazide binding affinity is 0.0335 mM, partial inhibition Neisseria meningitidis
N-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-2-nitrobenzamide binding affinity is 0.0209 mM, complete inhibition Neisseria meningitidis
N-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-3-nitrobenzamide binding affinity 0.0209 mM, inhibition of biliverdin production in Escherichia coli expressing the enzyme Neisseria meningitidis

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ essential requirement Neisseria meningitidis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
heme + AH2 + O2 Neisseria meningitidis
-
 biliverdin + Fe2+ + CO + A + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Neisseria meningitidis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme + AH2 + O2
-
 Neisseria meningitidis biliverdin + Fe2+ + CO + A + H2O
-
 ?