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Literature summary for 1.14.14.18 extracted from

  • Wang, J.; Evans, J.P.; Ogura, H.; La Mar, G.N.; Ortiz de Montellano, P.R.
    Alteration of the regiospecificity of human heme oxygenase-1 by unseating of the heme but not disruption of the distal hydrogen bonding network (2006), Biochemistry, 45, 61-73.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.14.18

Protein Variants

Protein Variants Comment Organism
D140A 21% activity compared to the wild type enzyme Homo sapiens
D140H 0.5% activity compared to the wild type enzyme Homo sapiens
D140K 7.1% activity compared to the wild type enzyme Homo sapiens
E29K 26% activity compared to the wild type enzyme Homo sapiens
K18A 114% activity compared to the wild type enzyme Homo sapiens
K18A/R183E 2% activity compared to the wild type enzyme Homo sapiens
K18A/Y134F/R183E 2% activity compared to the wild type enzyme Homo sapiens
K18E 92% activity compared to the wild type enzyme Homo sapiens
K18E/E29K/R183E 1.2% activity compared to the wild type enzyme Homo sapiens
K18E/R183E 3% activity compared to the wild type enzyme Homo sapiens
R183a 24% activity compared to the wild type enzyme Homo sapiens
R183E 2.8% activity compared to the wild type enzyme Homo sapiens
Y134F 76% activity compared to the wild type enzyme Homo sapiens
Y134F/R183E 2.8% activity compared to the wild type enzyme Homo sapiens
Y58A 46% activity compared to the wild type enzyme Homo sapiens
Y58A/D140A 13% activity compared to the wild type enzyme Homo sapiens
Y58F 38% activity compared to the wild type enzyme Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P09601
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme + 2 NADPH + 2 H+ + 2 O2
-
 Homo sapiens biliverdin + Fe2+ + CO + 2 NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
heme oxygenase-1
-
 Homo sapiens
Ho1
-
 Homo sapiens