Literature summary for 1.14.14.18 extracted from

Wang, J.; Niemevz, F.; Lad, L.; Huang, L.; Alvarez, D.E.; Buldain, G.; Poulos, T.L.; de Montellano, P.R.
Human heme oxygenase oxidation of 5- and 15-phenylhemes (2004), J. Biol. Chem., 279, 42593-42604.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
in complex with 5-phenylheme or 15-phenylheme	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P09601	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
protoheme + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 = biliverdin + Fe2+ + CO + 3 [oxidized NADPH-hemoprotein reductase] + 3 H2O	electrophilic oxidation mechanism, stereochemical control of the reaction regiospecificity	Homo sapiens	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
15-phenylheme + electron donor + O2	-	Homo sapiens	10-phenylbiliverdin IXalpha + Fe2+ + CO + oxidized eletron donor + H2O	-	?
5-phenylheme + electron donor + O2	-	Homo sapiens	biliverdin IXalpha + Fe2+ + CO + oxidized eletron donor + H2O + benzoic acid	-	?

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Release 2023.1 (January 2023)