Literature summary for 1.14.14.177 extracted from

Ohno, Y.; Nakamichi, S.; Ohkuni, A.; Kamiyama, N.; Naoe, A.; Tsujimura, H.; Yokose, U.; Sugiura, K.; Ishikawa, J.; Akiyama, M.; Kihara, A.
Essential role of the cytochrome P450 CYP4F22 in the production of acylceramide, the key lipid for skin permeability barrier formation (2015), Proc. Natl. Acad. Sci. USA, 112, 7707-7712 .

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Application

Application	Comment	Organism
medicine	CYP4F22 is one of the autosomal recessive congenital ichthyosis-causative genes. Ichthyosis-mutant proteins exhibit reduced enzyme activity. Lipid analysis of a patient with ichthyosis shows a drastic decrease in acylceramide production	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endoplasmic reticulum	type I membrane protein that locates in the endoplasmic reticulum	Homo sapiens	5783	-
membrane	type I membrane protein that locates in the endoplasmic reticulum	Homo sapiens	16020	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q6NT55	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293T cell	-	Homo sapiens	-
skin	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
C30:0 fatty acid + [reduced NADPH-hemoprotein reductase] + O2	-	Homo sapiens	C30:0 omega-hydroxy fatty acid + [oxidized NADPH-hemoprotein reductase] + H2O	-	?
additional information	the preferred substrates are fatty acids with a carbon chain length of 28 or more. Fatty acids of chain length C22 or C24 are not hydroxylated	Homo sapiens	?	-	-

Synonyms

Synonyms	Comment	Organism
CYP4F22	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	cytochrome P450 CYP4F22 (cytochrome P450, family 4, subfamily F, polypeptide 22) is an fatty acid omega-hydroxylase gene required for acylceramide production	Homo sapiens

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Release 2023.1 (January 2023)