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Literature summary for 1.14.14.176 extracted from
- Optimising the biosynthesis of oxygenated and acetylated taxol precursors in Saccharomyces cerevisiae using advanced bioprocessing strategies (2020), Biotechnol. Bioeng., 118, 279-293 .
Application
| Application | Comment | Organism |
|---|---|---|
| synthesis | engineered biosynthetic pathway for taxane production in Saccharomyces cerevisiae via chromosomal integration of Taxus cuspidata CYP725A4 and CPR genes. When expressed in the Saccharomyces cerevisiae strain, a potential T5alphaol isomer is the predominant product with maximum titers of 24 and 31 mg/l at micro and 1 l bioreactor scale, respectively. Total oxygenated taxane titers are improved to 78 mg/l and the acetylated acetylated T5alpha product is detected with a final titer of 3.7 mg/l | Taxus cuspidata |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Taxus cuspidata | Q6WG30 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CYP725A4 | - |
Taxus cuspidata |
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Release 2023.1 (January 2023)
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