Literature summary for 1.14.14.176 extracted from

Edgar, S.; Zhou, K.; Qiao, K.; King, J.R.; Simpson, J.H.; Stephanopoulos, G.
Mechanistic insights into taxadiene epoxidation by taxadiene-5alpha-hydroxylase (2016), ACS Chem. Biol., 11, 460-469 .

Search for more literature for 1.14.14.176

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Saccharomyces cerevisiae and Escherichia coli	Taxus cuspidata

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
taxa-4,11-diene + [reduced NADPH-hemoprotein reductase] + O2	Taxus cuspidata	-	taxa-4(20),11-dien-5alpha-ol + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Taxus cuspidata	Q6WG30	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
taxa-4,11-diene + [reduced NADPH-hemoprotein reductase] + O2	-	Taxus cuspidata	taxa-4(20),11-dien-5alpha-ol + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Synonyms

Synonyms	Comment	Organism
5alphaCYP	-	Taxus cuspidata
CYP725A4	-	Taxus cuspidata
taxadiene-5alpha-hydroxylase	-	Taxus cuspidata

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Release 2023.1 (January 2023)