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Literature summary for 1.14.14.176 extracted from
- Taxol biosynthetic genes (2001), Phytochemistry, 58, 1-7.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | enzyme may be useful in the biological production of the potent antimitotic drug taxol which shows activity against a range of cancers | Taxus cuspidata |
| medicine | enzyme may be useful in the biological production of the potent antimitotic drug taxol which shows activity against a range of cancers | Taxus brevifolia |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| taxa-4,11-diene + [reduced NADPH-hemoprotein reductase] + O2 | Taxus cuspidata | - |
taxa-4(20),11-dien-5alpha-ol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |  |
| taxa-4,11-diene + [reduced NADPH-hemoprotein reductase] + O2 | Taxus brevifolia | - |
taxa-4(20),11-dien-5alpha-ol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Taxus brevifolia | - |
- |
- |
| Taxus cuspidata | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| taxa-4,11-diene + [reduced NADPH-hemoprotein reductase] + O2 | - |
Taxus cuspidata | taxa-4(20),11-dien-5alpha-ol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| taxa-4,11-diene + [reduced NADPH-hemoprotein reductase] + O2 | - |
Taxus brevifolia | taxa-4(20),11-dien-5alpha-ol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
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