Literature summary for 1.14.14.175 extracted from

Scheler, U.; Brandt, W.; Porzel, A.; Rothe, K.; Manzano, D.; Bozic, D.; Papaefthimiou, D.; Balcke, G.; Henning, A.; Lohse, S.; Marillonnet, S.; Kanellis, A.; Ferrer, A.; Tissier, A.
Elucidation of the biosynthesis of carnosic acid and its reconstitution in yeast (2016), Nat. Commun., 7, 12942 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Saccharomyces cerevisiae	Salvia miltiorrhiza

Protein Variants

Protein Variants	Comment	Organism
D301E/N303S/V479F	mutation leads to a second oxidation of product to give 11-hydroxyferruginol, i.e. reaction of EC 1.14.14.60	Salvia miltiorrhiza

Organism

Organism	UniProt	Comment	Textmining
Salvia fruticosa	-	-	-
Salvia miltiorrhiza	S4UX02	-	-
Salvia rosmarinus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
abieta-8,11,13-triene + [reduced NADPH-hemoprotein reductase] + O2	-	Salvia miltiorrhiza	ferruginol + [oxidized NADPH-hemoprotein reductase] + H2O	-	?
abieta-8,11,13-triene + [reduced NADPH-hemoprotein reductase] + O2	enzymes carry out not a single but two successive oxidations leading to 11-hydroxyferruginol from abieta-8,11,13-triene, i.e. reactions of EC 1.14.14.175 and 1.14.14.60	Salvia rosmarinus	ferruginol + [oxidized NADPH-hemoprotein reductase] + H2O	-	?
abieta-8,11,13-triene + [reduced NADPH-hemoprotein reductase] + O2	enzymes carry out not a single but two successive oxidations leading to 11-hydroxyferruginol from abieta-8,11,13-triene, i.e. reactions of EC 1.14.14.175 and 1.14.14.60	Salvia fruticosa	ferruginol + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Synonyms

Synonyms	Comment	Organism
CYP76AH1	-	Salvia miltiorrhiza
Cyp76AH22	-	Salvia rosmarinus
Cyp76AH22	-	Salvia fruticosa
Cyp76AH23	-	Salvia rosmarinus
Cyp76AH23	-	Salvia fruticosa
CYP76AH24	-	Salvia rosmarinus
CYP76AH24	-	Salvia fruticosa

Cofactor

Cofactor	Comment	Organism	Structure
cytochrome P450	-	Salvia rosmarinus
cytochrome P450	-	Salvia miltiorrhiza
cytochrome P450	-	Salvia fruticosa

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Release 2023.1 (January 2023)