Protein Variants | Comment | Organism |
---|---|---|
additional information | RNAi-mediated silencing of CYP76AH1 in hairy roots, construction of a CYP76AH1 RNAi system for hairy roots using transformation via Agrobacterium rhizogenes strain C58C1. Metabolic analysis of RNAi-AH1 hairy root lines shows a significantly increased accumulation of miltiradiene and decreased concentration of ferruginol compared to the control lines. The content of tanshinones decreases significantly after silencing of CYP76AH1 | Salvia miltiorrhiza |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
abieta-8,11,13-triene + [reduced NADPH-hemoprotein reductase] + O2 | Salvia miltiorrhiza | - |
ferruginol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Salvia miltiorrhiza | S4UX02 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hairy root | - |
Salvia miltiorrhiza | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
abieta-8,11,13-triene + [reduced NADPH-hemoprotein reductase] + O2 | - |
Salvia miltiorrhiza | ferruginol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
abieta-8,11,13-triene + [reduced NADPH-hemoprotein reductase] + O2 | i.e. miltiradiene | Salvia miltiorrhiza | ferruginol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP76AH1 | - |
Salvia miltiorrhiza |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome P-450 | - |
Salvia miltiorrhiza | |
NADPH | - |
Salvia miltiorrhiza |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme catalyzes the first committed step in the biosynthesis of tanshinones, pathay overview | Salvia miltiorrhiza |
physiological function | CYP76AH1 catalyzes the conversion of the carbon skeleton miltiradiene into the intermediate ferruginol, which is involved in the biosynthesis of tanshinones, the chief bioactive ingredients of Salvia miltiorrhiza | Salvia miltiorrhiza |