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Literature summary for 1.14.14.172 extracted from

  • Li, J.; Huang, Y.; Hou, Y.; Li, X.; Cao, H.; Cui, Z.
    Novel gene clusters and metabolic pathway involved in 3,5,6-trichloro-2-pyridinol degradation by Ralstonia sp. strain T6 (2013), Appl. Environ. Microbiol., 79, 7445-7453 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.14.172

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli DH10B cells Ralstonia sp. T6

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3,5,6-trichloropyridin-2-ol + FADH2 + O2 Ralstonia sp. T6
-
 3,6-dichloropyridine-2,5-dione + Cl- + FAD + H2O
-
 ?
3,6-dichloropyridine-2,5-diol + FADH2 + O2 Ralstonia sp. T6
-
 6-chloro-3-hydroxypyridine-2,5-dione + Cl- + FAD + H2O
-
 ?
6-chloropyridine-2,3,5-triol + FADH2 + O2 Ralstonia sp. T6
-
 3,6-dihydroxypyridine-2,5-dione + Cl- + FAD + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Ralstonia sp. T6 L7VFL7
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,5,6-trichloropyridin-2-ol + FADH2 + O2
-
 Ralstonia sp. T6 3,6-dichloropyridine-2,5-dione + Cl- + FAD + H2O
-
 ?
3,6-dichloropyridine-2,5-diol + FADH2 + O2
-
 Ralstonia sp. T6 6-chloro-3-hydroxypyridine-2,5-dione + Cl- + FAD + H2O
-
 ?
6-chloropyridine-2,3,5-triol + FADH2 + O2
-
 Ralstonia sp. T6 3,6-dihydroxypyridine-2,5-dione + Cl- + FAD + H2O
-
 ?

Synonyms

Synonyms Comment Organism
tcpA
-
 Ralstonia sp. T6

Cofactor

Cofactor Comment Organism Structure
FADH2 the enzyme needs flavin reductase TcpX to supply FADH2 when transforming 3,5,6-trichloropyridin-2-ol Ralstonia sp. T6

General Information

General Information Comment Organism
malfunction an enzyme gene disruption mutant is not able to degrade 3,5,6-trichloropyridin-2-ol but 3,6-dihydroxypyridine-2,5-dione Ralstonia sp. T6
metabolism key enzyme in the initial step of 3,5,6-trichloropyridin-2-ol degradation Ralstonia sp. T6