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Literature summary for 1.14.14.17 extracted from

  • Godio, R.P.; Fouces, R.; Martin, J.F.
    A squalene epoxidase is involved in biosynthesis of both the antitumor compound clavaric acid and sterols in the basidiomycete H. sublateritium (2007), Chem. Biol., 14, 1334-1346.
    View publication on PubMed
Search for more literature for 1.14.14.17

Protein Variants

Protein Variants Comment Organism
additional information erg1 silencing in Hypholoma sublateritium, by expression of constructions using the gdh promoter of Agaricus bisporus, results in an ergosterol-dependnet phenotype for full growth, overexpression of erg1 results in 32%-97% increment of clavaric acid production, overview Hypholoma sublateritium

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ a cytochrome P450 enzyme Hypholoma sublateritium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
squalene + AH2 + O2 Hypholoma sublateritium oxidosqualene or dioxidosqualene appears to be the branching point for primary metabolism and secondary metabolites in basidiomycetes (S)-squalene-2,3-epoxide + A + H2O
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 ?

Organism

Organism UniProt Comment Textmining
Hypholoma sublateritium
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 a basidiomycete, gene erg1
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
squalene + AH2 + O2
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 Hypholoma sublateritium (S)-squalene-2,3-epoxide + A + H2O
-
 ?
squalene + AH2 + O2 oxidosqualene or dioxidosqualene appears to be the branching point for primary metabolism and secondary metabolites in basidiomycetes Hypholoma sublateritium (S)-squalene-2,3-epoxide + A + H2O
-
 ?

Cofactor

Cofactor Comment Organism Structure
cytochrome P450 required Hypholoma sublateritium
FAD required Hypholoma sublateritium
NADPH required Hypholoma sublateritium