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Literature summary for 1.14.14.17 extracted from

  • Ryder, N.S.; Dupont, M.C.
    Inhibition of squalene epoxidase by allylamine antimycotic compounds. A comparative study of the fungal and mammalian enzymes (1985), Biochem. J., 230, 765-770.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
(E)-N-(6,6-dimethylhept-2-en-4-ynyl)-N-methyl-1-naphthalenemethaneamine hydrochloride i.e. compound SF 86-327, non-competitive inhibition Candida albicans
(E)-N-(6,6-dimethylhept-2-en-4-ynyl)-N-methyl-1-naphthalenemethaneamine hydrochloride i.e. compound SF 86-327, non-competitive inhibition Candida parapsilosis
(E)-N-(6,6-dimethylhept-2-en-4-ynyl)-N-methyl-1-naphthalenemethaneamine hydrochloride i.e. compound SF 86-327, non-competitive inhibition Rattus norvegicus
(E)-N-methyl-N-(3-phenylprop-2-enyl)-1-naphthalenemethaneamine i.e. naftifine, non-competitive inhibition Candida albicans
(E)-N-methyl-N-(3-phenylprop-2-enyl)-1-naphthalenemethaneamine i.e. naftifine, non-competitive inhibition Candida parapsilosis
(E)-N-methyl-N-(3-phenylprop-2-enyl)-1-naphthalenemethaneamine i.e. naftifine, non-competitive inhibition Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.011
-
 squalene
-
 Rattus norvegicus
0.016
-
 squalene
-
 Candida parapsilosis
0.05
-
 squalene
-
 Candida albicans

Organism

Organism UniProt Comment Textmining
Candida albicans
-
-
-
Candida parapsilosis
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
squalene + NAD(P)H + O2 NADPH is preferred Rattus norvegicus (S)-squalene-2,3-epoxide + NADP+ + H2O
-
 ?
squalene + NAD(P)H + O2 NADH is preferred Candida albicans (S)-squalene-2,3-epoxide + NADP+ + H2O
-
 ?
squalene + NAD(P)H + O2 NADH is preferred Candida parapsilosis (S)-squalene-2,3-epoxide + NADP+ + H2O
-
 ?

Cofactor

Cofactor Comment Organism Structure
FAD required for activity Rattus norvegicus
FAD required for activity Candida albicans
FAD required for activity Candida parapsilosis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00003
-
 (E)-N-(6,6-dimethylhept-2-en-4-ynyl)-N-methyl-1-naphthalenemethaneamine hydrochloride
-
 Candida albicans
0.00004
-
 (E)-N-(6,6-dimethylhept-2-en-4-ynyl)-N-methyl-1-naphthalenemethaneamine hydrochloride
-
 Candida parapsilosis
0.00034
-
 (E)-N-methyl-N-(3-phenylprop-2-enyl)-1-naphthalenemethaneamine
-
 Candida parapsilosis
0.0011
-
 (E)-N-methyl-N-(3-phenylprop-2-enyl)-1-naphthalenemethaneamine
-
 Candida albicans
0.077
-
 (E)-N-(6,6-dimethylhept-2-en-4-ynyl)-N-methyl-1-naphthalenemethaneamine hydrochloride
-
 Rattus norvegicus
1.44
-
 (E)-N-methyl-N-(3-phenylprop-2-enyl)-1-naphthalenemethaneamine
-
 Rattus norvegicus