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Literature summary for 1.14.14.16 extracted from

  • Yoshimoto, F.K.; Peng, H.M.; Zhang, H.; Anderson, S.M.; Auchus, R.J.
    Epoxidation activities of human cytochromes P450c17 and P450c21 (2014), Biochemistry, 53, 7531-7540 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
V359A mutant displays significant 16alpha-hydroxylase activity. Substrate 16,17-dehydroprogesterone is converted to the 21-hydroxylated product and slightly more epoxide than wild-type Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P08686
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
16,17-dehydroprogesterone + NADPH + O2
-
Homo sapiens 16,17-dehydro-21-hydroxyprogesterone + NADP+ + H2O
-
?

Synonyms

Synonyms Comment Organism
P450c21
-
Homo sapiens