Cloned (Comment) | Organism |
---|---|
recombinant expression in yeast microsomes | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ketoconazole | inhibits hydroxylation activity with progesterone and 17-fluoroprogesterone to the same amount | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
17alpha-hydroxyprogesterone + [reduced NADPH-P450 reductase] + O2 | Homo sapiens | - |
11-deoxycortisol + [oxidized NADPH-P450 reductase] + H2O | - |
? | |
progesterone + [reduced NADPH-P450 reductase] + O2 | Homo sapiens | - |
11-deoxycorticosterone + [oxidized NADPH-P450 reductase] + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
17-fluoro-progesterone + [reduced NADPH-P450 reductase] + O2 | - |
Homo sapiens | 17-fluoro-11-deoxycorticosterone + [oxidized NADPH-P450 reductase] + H2O | - |
? | |
17alpha-hydroxyprogesterone + [reduced NADPH-P450 reductase] + O2 | - |
Homo sapiens | 11-deoxycortisol + [oxidized NADPH-P450 reductase] + H2O | - |
? | |
additional information | 21-trifluorosteroids mht by a substrates for CYP21A2, substrate specificity analysis of CP21A2 with diverse halogenated steroid substrates, e.g. introducing one or more halogen atom to the 17- and 21-positions of progesterone and pregnenolone, 21,21,21-tribromoprogesterone and 21,21,21-trichloroprogesterone, overview | Homo sapiens | ? | - |
? | |
progesterone + [reduced NADPH-P450 reductase] + O2 | - |
Homo sapiens | 11-deoxycorticosterone + [oxidized NADPH-P450 reductase] + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
21-hydroxylase | - |
Homo sapiens |
CYP21A2 | - |
Homo sapiens |
P450c21 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | deficiency of CYP21A2 leading to congenital adrenal hyperplasia, is the most common autosomal recessive disease in human beings | Homo sapiens |
physiological function | human steroidogenic cytochrome P450 CYP21A2 is required for the biosynthesis of androgens, glucocorticoids, and mineralocorticoids | Homo sapiens |