Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.14.16 extracted from

  • Yoshimoto, F.K.; Desilets, M.C.; Auchus, R.J.
    Synthesis of halogenated pregnanes, mechanistic probes of steroid hydroxylases CYP17A1 and CYP21A2 (2012), J. Steroid Biochem. Mol. Biol., 128, 38-50.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression in yeast microsomes Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
ketoconazole inhibits hydroxylation activity with progesterone and 17-fluoroprogesterone to the same amount Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
17alpha-hydroxyprogesterone + [reduced NADPH-P450 reductase] + O2 Homo sapiens
-
11-deoxycortisol + [oxidized NADPH-P450 reductase] + H2O
-
?
progesterone + [reduced NADPH-P450 reductase] + O2 Homo sapiens
-
11-deoxycorticosterone + [oxidized NADPH-P450 reductase] + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17-fluoro-progesterone + [reduced NADPH-P450 reductase] + O2
-
Homo sapiens 17-fluoro-11-deoxycorticosterone + [oxidized NADPH-P450 reductase] + H2O
-
?
17alpha-hydroxyprogesterone + [reduced NADPH-P450 reductase] + O2
-
Homo sapiens 11-deoxycortisol + [oxidized NADPH-P450 reductase] + H2O
-
?
additional information 21-trifluorosteroids mht by a substrates for CYP21A2, substrate specificity analysis of CP21A2 with diverse halogenated steroid substrates, e.g. introducing one or more halogen atom to the 17- and 21-positions of progesterone and pregnenolone, 21,21,21-tribromoprogesterone and 21,21,21-trichloroprogesterone, overview Homo sapiens ?
-
?
progesterone + [reduced NADPH-P450 reductase] + O2
-
Homo sapiens 11-deoxycorticosterone + [oxidized NADPH-P450 reductase] + H2O
-
?

Synonyms

Synonyms Comment Organism
21-hydroxylase
-
Homo sapiens
CYP21A2
-
Homo sapiens
P450c21
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

General Information

General Information Comment Organism
malfunction deficiency of CYP21A2 leading to congenital adrenal hyperplasia, is the most common autosomal recessive disease in human beings Homo sapiens
physiological function human steroidogenic cytochrome P450 CYP21A2 is required for the biosynthesis of androgens, glucocorticoids, and mineralocorticoids Homo sapiens