Cloned (Comment) | Organism |
---|---|
mutant enzymes are expressed in COS-7 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
K122Q | missense mutation causing nonclassical 21-hydroxylase deficiency, shows reduced activity of 14% for the conversion of 17alpha-hydroxyprogesterone and 19% for the conversion of progesterone compared to wild type | Homo sapiens |
P453S | the mutant shows a reduced activity of 36% of wild type for the conversion of 17alpha-hydroxyprogesterone and 44% for the conversion of progesterone | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0015 | - |
progesterone | wild type enzyme | Homo sapiens | |
0.0015 | - |
progesterone | mutant enzyme P453S | Homo sapiens | |
0.0016 | - |
17alpha-hydroxyprogesterone | wild type enzyme | Homo sapiens | |
0.002 | - |
17alpha-hydroxyprogesterone | mutant enzyme P453S | Homo sapiens | |
0.0024 | - |
progesterone | mutant enzyme K121Q | Homo sapiens | |
0.0026 | - |
17alpha-hydroxyprogesterone | mutant enzyme K121Q | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
17alpha-hydroxyprogesterone + AH2 + O2 | - |
Homo sapiens | 11-deoxycortisol + A + H2O | - |
? | |
progesterone + AH2 + O2 | - |
Homo sapiens | deoxycorticosterone + A + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
21-hydroxylase | - |
Homo sapiens |
CYP21 | - |
Homo sapiens |
P450 oxidoreductase-21-hydroxylase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome P450 | - |
Homo sapiens |