Protein Variants | Comment | Organism |
---|---|---|
A15T | natural mutation found in patients with classical congenital adrenal hyperplasia, no significant difference in activity compared to wild-type | Homo sapiens |
P482S | natural mutation found in patients with nonclassical congenital adrenal hyperplasia, precocious pubarche, menstrual irregularities or hypertrichosis, about 70% of activity compared to wild-type | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2.3 | - |
17-hydroxy-progesterone | 37°C, mutant P482S | Homo sapiens | |
3 | - |
progesterone | 37°C, mutant P482S | Homo sapiens | |
6.4 | - |
progesterone | 37°C, wild-type | Homo sapiens | |
8.5 | - |
17-hydroxy-progesterone | 37°C, wild-type | Homo sapiens | |
9.2 | - |
progesterone | 37°C, mutant A15T | Homo sapiens | |
9.2 | - |
17-hydroxy-progesterone | 37°C, mutant A15T | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00027 | - |
37°C, mutant P482S, substrate 17-hydroxy-progesterone | Homo sapiens |
0.00038 | - |
37°C, mutant P482S, substrate progesterone | Homo sapiens |
0.00117 | - |
37°C, wild-type, substrate progesterone | Homo sapiens |
0.00122 | - |
37°C, wild-type, substrate 17-hydroxy-progesterone | Homo sapiens |
0.00129 | - |
37°C, mutant A15T, substrate 17-hydroxy-progesterone | Homo sapiens |
0.00148 | - |
37°C, mutant A15T, substrate progesterone | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
17-hydroxy-progesterone + NADH + O2 | - |
Homo sapiens | 17-hydroxy-11-deoxy-corticosterone + NAD+ + H2O | - |
? | |
progesterone + NADH + O2 | - |
Homo sapiens | deoxycorticosterone + NAD+ + H2O | - |
? |