Literature summary for 1.14.14.154 extracted from

Borcea, A.; Marc, G.; Pirnau, A.; Vlase, L.; Ionut, I.; Tiperciuc, B.; Oniga, O.
Synthesis and molecular docking study of some new 1,4-phenylene-bisthiazoles as fungal lanosterol 14alpha-demethylase inhibitors (2017), Farmacia, 65, 683-689 .

No PubMed abstract available

Search for more literature for 1.14.14.154

Inhibitors

Inhibitors	Comment	Organism	Structure
1-(4-methyl-2-(4-(2-methylthiazol-4-yl)phenyl)thiazol-5-yl)ethanone	the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study	Candida albicans SC5314
2-hydroxy-5-(2-(4-(2-methylthiazol-4-yl)phenyl)thiazol-4-yl)benzamide	the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study	Candida albicans SC5314
2-methyl-4-(4-(4-(naphthalen-1-yl)thiazol-2-yl)phenyl)-thiazole	the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study	Candida albicans SC5314
2-methyl-4-(4-(4-phenylthiazol-2-yl)phenyl)thiazole	the compounds is predicted to be a non-competitive inhibitors of the enzyme by molecular docking study	Candida albicans SC5314
4-(2-(4-(2-methylthiazol-4-yl)phenyl)thiazol-4-yl)-benzonitrile	the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study	Candida albicans SC5314
4-(4-chlorophenyl)-2-(4-(2-methylthiazol-4-yl)phenyl)-thiazole	the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study	Candida albicans SC5314
4-(4-methoxyphenyl)-2-(4-(2-methylthiazol-4-yl)-phenyl)thiazole	the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study	Candida albicans SC5314
4-(chloromethyl)-2-(4-(2-methylthiazol-4-yl)phenyl)-thiazole	the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study	Candida albicans SC5314
ethyl 2-(2-(4-(2-methylthiazol-4-yl)phenyl)thiazol-4-yl)acetate	the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study	Candida albicans SC5314
ethyl 4-methyl-2-(4-(2-methylthiazol-4-yl)phenyl)-thiazole-5-carboxylate	the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study	Candida albicans SC5314

Organism

Organism	UniProt	Comment	Textmining
Candida albicans SC5314	P10613	-	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)