Protein Variants | Comment | Organism |
---|---|---|
F145A | the mutation leads to a serious weakening of steroid ligand binding | Homo sapiens |
I383A | the mutation leads to a serious weakening of steroid ligand binding | Homo sapiens |
R388A | the mutation leads to a serious weakening of steroid ligand binding | Homo sapiens |
V149A | the mutation leads to a serious weakening of steroid ligand binding | Homo sapiens |
Y137A | the mutation leads to a serious weakening of steroid ligand binding | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | - |
24,25-dihydro-4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | - |
4,4-dimethylcholesta-8,14,24-trien-3-ol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | - |
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16850 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 24,25-dihydro-4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 4,4-dimethylcholesta-8,14,24-trien-3-ol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP51A1 | - |
Homo sapiens |
lanosterol 14alpha-demethylase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | CYP51A1 is involved in the cholesterol biosynthesis pathway | Homo sapiens |