Protein Variants | Comment | Organism |
---|---|---|
additional information | direct electron transfer is measured between CYP51 and graphite screen-printed electrodes modified with gold nanoparticles and with the membrane-like synthetic surfactant didodecyl dimethylammonium bromide, determination of the formal potential of the Fe3+/Fe2+ pair, detailed overview, lanosterol addition to the oxygenated solution causes a concentration-dependent increase in the reduction current in voltammetric and amperometric experiments | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ketoconazole | - |
Mycobacterium tuberculosis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | a cytochrome P450 enzyme | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
lanosterol + O2 + NADPH + H+ | Mycobacterium tuberculosis | - |
4,4-dimethyl-5alpha-cholesta-8,14,24-triene-3beta-ol + formate + NADP+ + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
lanosterol + O2 + NADPH + H+ | - |
Mycobacterium tuberculosis | 4,4-dimethyl-5alpha-cholesta-8,14,24-triene-3beta-ol + formate + NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP51 | - |
Mycobacterium tuberculosis |
CYP51b1 | - |
Mycobacterium tuberculosis |
sterol-14alpha-demethylase | - |
Mycobacterium tuberculosis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome P450 | a cytochrome P450 enzyme | Mycobacterium tuberculosis |