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Literature summary for 1.14.14.154 extracted from

  • Van Nistelrooy, J.G.M.; Van den Brink, J.M.; Van Kan, J.A.L.; Van Gorcom, R.F.M.; de Waard, M.A.
    Isolation and molecular characterisation of the gene encoding eburicol 14alpha-demethylase (CYP51) from Penicillium italicum (1996), Mol. Gen. Genet., 250, 725-733.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
cDNA, introduced into Aspergillus niger by transformation Penicillium italicum

Inhibitors

Inhibitors Comment Organism Structure
fungicides
-
Penicillium italicum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
57300
-
amino acid analysis Penicillium italicum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
eburicol + [reduced NADPH-hemoprotein reductase] + O2 Penicillium italicum
-
? + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Organism

Organism UniProt Comment Textmining
Candida albicans
-
-
-
Candida tropicalis
-
-
-
Penicillium italicum
-
filamentous fungal plant pathogen
-
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
eburicol + O2 + [reduced NADPH-hemoprotein reductase] + O2
-
Penicillium italicum 2-(3-hydroxy-4,4,10,13-tetramethyl-2,3,4,5,6,7,10,11,12,13,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-methyl-5-methylene-heptanoic acid + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
eburicol + [reduced NADPH-hemoprotein reductase] + O2
-
Penicillium italicum ? + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 lanosta-8,24-dien-3beta-ol Saccharomyces cerevisiae 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 lanosta-8,24-dien-3beta-ol Candida albicans 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 lanosta-8,24-dien-3beta-ol Candida tropicalis 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 4,4,14alpha-trimethyl-5alpha-cholesta-8,24-dien-3beta-ol Saccharomyces cerevisiae 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 4,4,14alpha-trimethyl-5alpha-cholesta-8,24-dien-3beta-ol Candida albicans 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 4,4,14alpha-trimethyl-5alpha-cholesta-8,24-dien-3beta-ol Candida tropicalis 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Cofactor

Cofactor Comment Organism Structure
cytochrome P450
-
Saccharomyces cerevisiae
cytochrome P450
-
Candida albicans
cytochrome P450
-
Candida tropicalis
cytochrome P450
-
Penicillium italicum
heme heme-thiolate enzyme Saccharomyces cerevisiae
heme heme-thiolate enzyme Candida albicans
heme heme-thiolate enzyme Candida tropicalis
heme heme-thiolate enzyme Penicillium italicum